Cover of: Cell Repopulation of Bioprosthetic Heart Valves | Jessa Yperman Read Online

Cell Repopulation of Bioprosthetic Heart Valves

  • 292 Want to read
  • ·
  • 25 Currently reading

Published by Leuven Univ Pr .
Written in English


  • Cardiology,
  • Medical

Book details:

Edition Notes

Acta Biomedica Lovaniensia

The Physical Object
Number of Pages142
ID Numbers
Open LibraryOL12846145M
ISBN 109058675475
ISBN 109789058675477

Download Cell Repopulation of Bioprosthetic Heart Valves


Bioengineered valves obtained from acellular non-valvular scaffolds or decellularized native valves are proving to be a compelling alternative to mechanical and bioprosthetic valve implants, as they appear to permit repopulation by the host’s own cells with associated tissue remodelling, growth and repair, besides showing less propensity to calcification and adequate Cited by: 1. Bioprosthetic heart valves have evolved over the years into remarkably useful and predictable devices. During this process, a number of specific designs . A framework for designing patient-specific bioprosthetic heart valves using immersogeometric fluid– structure interaction analysis. International journal for numerical methods in biomedical engineering, 34(4):e, Computational Modeling Frameworks for BHVs •Reconstruct the heart valve from medical imagesFile Size: 6MB. Xenotransplantation of decellularized heart valves might be the final solution to overcome the shortage of homograft donors, hence avoiding glutaraldehyde fixation used for heart valve bioprostheses.

Abstract: Despite the significant advances in cardiac surgery, heart valve replacement still faces a dilemma. While mechanical valves offer lifelong durability they also commit patients to anticoagulation treatment for the rest of their by: 8. Before implantation in patients, bioprosthetic heart valves may be stored for varying periods in buffered glutaraldehyde solution. Although manufacturers recommend some precautions for the storage of valvular bioprostheses, no standardized conditions exist for the storage temperature and the period of time in by: Bioprosthetic valves are generally treated with glutaraldehyde (GA) to stabilize the tissue by preventing rejection of the xenogenic scaffold. However, such treatments stiffen the fiber network and diminish the cushioning function of the spongiosa layer. In addition, GA is toxic and inhibits the repopulation of cells after by:   Abstract. The valves of the heart cannot regenerate spontaneously. Therefore, heart valve disease generally necessitates surgical repair or replacement of the diseased tissue by mechanical or bioprosthetic valve substitutes in order to avoid potentially fatal cardiac or systemic consequences. Although survival and quality.

Prosthetic heart valves are commonly used in the treatment of valvular heart disease. Mechanical valves are more durable than the bioprosthetic valves; however, the need for long-term anticoagulant therapy renders them unsuitable for some patient groups. In this paper we discuss the different types and models of bioprosthesis, and in particular, pericardial Cited by: logical characterization of bioartificial human heart valves based on. trypsin digestion The authors demonstrated the efficacy of produc-. ing cell-free aortic and pulmonary valves in a scaffold with a DNA re-. duction of more than 98% as compared with native untreated by: Abstract. Cardiac valves are dynamic structures, that remodel in response to changes in local mechanical\ud forces, and exhibit a complex architecture highly specialized, consisting of cells and extracellular\ud matrix enriched in proteoglycans, glycosaminoglycans (GAGs), collagen and elastic fibers.\ud Typical valve substitutes are mechanical prostheses and : Antonio Cigliano. Mechanical valve replacements are made from very durable materials such as titanium and carbon. Tissue heart valve replacements, also known as biological or bioprosthetic valves, are harvested from pigs (porcine heart valves) or constructed from the tissue sac (the pericardium) surrounding the heart of a cow (bovine).